Clostridium difficile: An Important Opportunistic Pathogen in Healthcare-Associated Infections
A close up photo of gloved hands holding a petri dish of C. diff culture
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Keywords

Infectious Diseases
Clostridium difficile

How to Cite

Ahn, Soohyoun, and Amarat Simonne. 2018. “Clostridium Difficile: An Important Opportunistic Pathogen in Healthcare-Associated Infections: FSHN14-07/FS253, Rev. 1/2018”. EDIS 2018 (1). Gainesville, FL. https://doi.org/10.32473/edis-fs253-2018.

Abstract

Healthcare-associated infections are infections that patients can get while receiving medical treatment in a healthcare facility. One opportunistic pathogen, Clostridium difficile, has been getting more attention in recent years because of its association with antibiotic use and a high death rate among the elderly. This 7-page factsheet will provide an overview of Clostridium difficile infection (CDI) with a focus on healthcare-associated infections. Written by Soohyoun Ahn and Amarat H. Simonne and published by the UF/IFAS Department of Food Science and Human Nutrition, January 2018.
http://edis.ifas.ufl.edu/fs253

https://doi.org/10.32473/edis-fs253-2018
view on EDIS
PDF-2018

References

Banas, J. A. 2004. "Virulence properties of Streptococcus mutans." Front Biosci 9:1267-1277. https://doi.org/10.2741/1305

Bassetti, M., G. Villa, and D. Pecori. 2014. "Antibiotic-resistant Pseudomonas aeruginosa: focus on care in patients receiving assited ventilation." Future Microbiol 9:465-474. https://doi.org/10.2217/fmb.14.7

Centers for Disease Control and Prevention (CDC). 2014. "Diseases and organisms in healthcare settings." Last accessed on November 6, 2017. http://www.cdc.gov/HAI/organisms/organisms.html

Centers for Disease Control and Prevention (CDC). 2015. "Clostridium difficile infection information for patients." Last accessed on November 30, 2017. https://www.cdc.gov/hai/organisms/cdiff/cdiff-patient.html

Centers for Disease Control and Prevention (CDC). 2016a. "HAI data and statistics." Last accessed on November 3, 2017. https://www.cdc.gov/hai/surveillance/index.html

Centers for Disease Control and Prevention (CDC). 2016b. "Clostridium difficile infection (CDI) - Prevention primer." Last accessed on November 14, 2017. https://www.cdc.gov/hai/pdfs/toolkits/cdi-primer-2-2016.pdf

Chroneou, A., N. Zias, J. F. Beamis, Jr, and D. E. Craven. 2007. "Healthcare-associated pneumonia: principles and emerging concepts on management." Expert Opin Pharmacother. 8:3117-3131. https://doi.org/10.1517/14656566.8.18.3117

Danziger-Isakov, L. 2014. "Gastrointestinal infections after transplantation." Curr Opin Gastroenterol 30:40-46. https://doi.org/10.1097/MOG.0000000000000016

Dubberke, E. R., and D. N. Gerding. 2011. "Rationale for hand hygiene recommendations after caring for a patient with Clostridium difficile infection." Last accessed on November 30, 2017. https://www.shea-online.org/images/patients/CDI-hand-hygiene-Update.pdf

Hookman, P., and J. S. Barkin. 2009. "Clostridium difficile associated infection, diarrhea and colitis." World J. Gastroenterol. 15:1554-1580. https://doi.org/10.3748/wjg.15.1554

Kelly, C. P., and J. T. Lamont. 2014. "Clostridium difficile in adults: treatment." Last accessed on November 30, 2017. http://www.uptodate.com/contents/clostridium-difficile-in-adults-treatment

Kerr, K. G. and A. M. Snelling. 2009. "Pseudomonas aeruginosa: a formidable and ever-present adversary." J. Hosp. Infect. 73:338-344. https://doi.org/10.1016/j.jhin.2009.04.020

Klevens, R. M., J. R. Edwards, C. L. Richards, Jr., T. C. Horan, R. P. Gaynes, D. A. Pollock, and D. M. Cardo. 2002. "Estimating health care-associated infections and deaths in US hospitals. Public Health Rep. 122:160-166. https://doi.org/10.1177/003335490712200205

Knoop, F. C., M. Owens, and I. C. Crocker. 1993. "Clostridium difficile: clinical disease and diagnosis." Clin. Microbiol. Rev. 6:251-265. https://doi.org/10.1128/CMR.6.3.251

Kochanek, K. D., S. L. Murphy, J. Xu, and B. Tejada-Vera. 2016. "Deaths: final data for 2014." Natl Vital Stat Rep 65:1-122. Last accessed on November 30, 2017. https://www.cdc.gov/nchs/data/nvsr/nvsr65/nvsr65_04.pdf

Kuehn, B. M. 2011. "Scientists seek strategies to prevent Clostridium difficile infections." JAMA 306:1849-1850. https://doi.org/10.1001/jama.2011.1569

Kyi, C., M. D. Hellmann, J. D. Wolchok, P. B. Chapman, and M. A. Postow. 2014. "Opportunistic infections in patients treated with immunotherapy for cancer." J. Immunother Cancer. 2:19. https://doi.org/10.1186/2051-1426-2-19

Leffler, D. A. and J. T. Lamont. 2015. "Clostridium difficile infection." N. Engl. J. Med. 372:1539-1548. https://doi.org/10.1056/NEJMra1403772

Lessa, F. C., L. G. Winston, L. C. McDonald, and Emerging Infections Program C. difficile Surveillance Team. 2015. "Burden of Clostridium difficile infection in the United States." N. Engl. J. Med. 372:2369-2370. https://doi.org/10.1056/NEJMc1505190

Loo, V. G., P. Brassard, and M. A. Miller. 2016. "Household transmission of Clostridium difficile to family members and domestic pets." Infect. Control Hosp. Epidemiol. 37:1342-1348. https://doi.org/10.1017/ice.2016.178

Magill, S. S., J. R. Edwards, W. Bamberg, Z. G. Beldavs, G. Dumyati, M. A. Kainer, R. Lynfield, R. et al. 2014. "Multistate point-prevalence survey of health care-associated infections." N. Engl. J. Med. 370:1198-1208. https://doi.org/10.1056/NEJMoa1306801

Napolitano, L. M. and C. E. Edmiston Jr. 2017. "Clostridium difficile disease: Diagnosis, pathogenesis, and treatment update." Surgery 162:325-348. https://doi.org/10.1016/j.surg.2017.01.018

Norén, T. 2010. "Clostridium difficile and the disease it causes." Methods Mol. Biol. 646:9-35. https://doi.org/10.1007/978-1-60327-365-7_2

Pagano, L., and M. Caira. 2012. "Risks for infection in patients with myelodysplasia and acute leukemia." Currn Opin Infect Dis. 25:612-618. https://doi.org/10.1097/QCO.0b013e328358b000

Pépin, J., L. Valiquette, and B. Cossette. 2005. "Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec." CMAJ. 173:1037-1042. https://doi.org/10.1503/cmaj.050978

Rohlke, F. and N. Stollman. 2012. "Fecal microbiota transplantation in relapsing Clostridium difficile infection." Therap. Adv. Gastroenterol. 5:403-420. https://doi.org/10.1177/1756283X12453637

Scott, R. D. II. 2009. "The direct medical costs of healthcare-associated infections in US hospitals and the benefits of prevention." Last accessed on November 6, 2017. http://www.cdc.gov/hai/pdfs/hai/scott_costpaper.pdf

Sehulster, L., and R. Y. W. Chinn. 2003. "Guidelines for environmental infection control in health-care facilities: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC)." MMWR 52:1-42.

Siegel, J. D., E. Rhinehart, M. Jackson, L. Chiarello, and the Healthcare Infection Control Practices Advisory Committee. 2007. "2007 Guideline for isolation precautions: preventing transmission of infectious agents in healthcare settings." Last accessed on November 30, 2017. https://www.cdc.gov/infectioncontrol/pdf/guidelines/isolation-guidelines.pdf https://doi.org/10.1016/j.ajic.2007.10.007

Squellati, R. 2017. "Evidence-based practice in the treatment for antibiotic-associated diarrhea in the intensive care unit." Crit. Care Nurs. Clin. North Am. https://doi.org/10.1016/j.cnc.2017.10.008. https://doi.org/10.1016/j.cnc.2017.10.008

Steiner, C., M. Barrett, and Y. Sun. 2015. "HCUP Projections: Clostridium Difficile Hospitalizations 2004-2015. 2015. HCUP Projections Report #2015-02." Last accessed on Nov 15, 2017. https://www.hcup-us.ahrq.gov/reports/projections/2015-02.pdf

Stone, N. E., L. C. Sidak-Loftis, J. W. Sahl, A. J. Vazquez, K. B. Wiggins, J. D. Gillece et al. 2016. "More than 50% of Clostridium difficile isolates from pet dogs in Flagstaff, USA, carry toxigenic genotypes." PLOS One 11:e0164504. https://doi.org/10.1371/journal.pone.0164504

Teter, J, Florida Department of Health, Division of Disease Control and Health Protection. 2015. "Clostridium difficile diagnoses during hospitalizations, Florida, 2008-2013." Last accessed on November 28, 2017. http://www.floridahealth.gov/diseases-and-conditions/clostridium-difficile/_documents/clostridium-difficile-diagnoses-during-hospitalizations.pdf.

Tredget, E. E., H. A. Shankowsky, R. Rennie, R. E. Burrell, and S. Logsetty. 2004. "Pseudomonas infections in the thermally injured patient." Burns 30:3-26. https://doi.org/10.1016/j.burns.2003.08.007

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