Facts about Wildlife Diseases: Malignant Catarrhal Fever (MCF)
Paynes Prairie, deer, grass, trees. UF/IFAS Photo: Josh Wickham.
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Keywords

malignant catarrhal fever
white-tailed deer
Odocoileus virginianus
viral diseases of animals and humans
livestock diseases

Categories

How to Cite

Sizemore, Braxton, and Juan Manuel Campos Krauer. 2025. “Facts about Wildlife Diseases: Malignant Catarrhal Fever (MCF): VM269, 2 2025”. EDIS 2025 (2). Gainesville, FL. https://doi.org/10.32473/edis-vm269-2025.

Abstract

Malignant catarrhal fever (MCF) is a viral infection of a wide variety of ruminant species and, in rare cases, swine. This publication discusses common clinical signs of MCF as well as prevention and treatment of MCF infection. Written by Braxton Sizemore and Juan Manuel Campos Krauer, and published by the UF College of Veterinary Medicine, UF/IFAS Extension, February 2025.

https://doi.org/10.32473/edis-vm269-2025
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References

Aiello, S. E., and M. A. Moses. 2016. “Malignant Catarrhal Fever.” In The Merck Veterinary Manual. 11th ed. 758–760. Merck and Co.

Berezowski, J. A., G. D. Appleyard, T. B. Crawford, J. Haigh, H. Li, D. M. Middleton, B. P. O’Connor, K. West, and M. Woodbury. 2005. “An Outbreak of Sheep-Associated Malignant Catarrhal Fever in Bison (Bison bison) After Exposure to Sheep at a Public Auction Sale.” Journal of Veterinary Diagnostic Investigation 17 (1): 55–58. https://doi.org/10.1177/104063870501700110

Brown, C. C., and L. L. Bloss. 1992. “An Epizootic of Malignant Catarrhal Fever in a Large Captive Herd of White-Tailed Deer (Odocoileus virginianus).” Journal of Wildlife Diseases 28 (2): 301–305. https://doi.org/10.7589/0090-3558-28.2.301

Kleiboeker, S. B., M. A. Miller, S. K. Schommer, J. A. Ramos-Vara, M. Boucher, and S. E. Turnquist. 2002. “Detection and Multigenic Characterization of a Herpesvirus Associated with Malignant Catarrhal Fever in White-Tailed Deer (Odocoileus virginianus) from Missouri.” Journal of Clinical Microbiology 40 (4): 1311–1318. https://doi.org/10.1128/jcm.40.4.1311-1318.2002

Lankester, F., A. Lugelo, R. Kazwala, J. Keyyu, S. Cleaveland, and J. Yoder. 2015. “The Economic Impact of Malignant Catarrhal Fever on Pastoralist Livelihoods.” PLoS ONE 10 (1): e0116059. https://doi.org/10.1371/journal.pone.0116059

Li, H., C. W. Cunha, B. Abbitt, T. W. deMaar, S. D. Lenz, J. R. Hayes, and N. S. Taus. 2013. “Goats Are a Potential Reservoir for the Herpesvirus (MCF-WTD), Causing Malignant Catarrhal Fever in Deer.” Journal of Zoo and Wildlife Medicine 44 (2): 484–486. https://doi.org/10.1638/2012-0087R.1

Li, H., C. W. Cunha, N. S. Taus, and D. P. Knowles. 2014. “Malignant Catarrhal Fever: Inching Toward Understanding.” Annual Review of Animal Biosciences 2 (2): 209–233. https://doi.org/10.1146/annurev-animal-022513-114156

Li, H., G. Karney, D. O’Toole, and T. B. Crawford. 2008. “Long Distance Spread of Malignant Catarrhal Fever Virus from Feedlot Lambs to Ranch Bison.” The Canadian Veterinary Journal 49 (2): 183–185.

Reid, H. W., and D. Buxton. 1984. “Malignant Catarrhal Fever of Deer.” Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences 82 (4): 261–273. https://doi.org/10.1017/S026972700000378X

Schultheiss, P. C., J. K. Collins, L. E. Austgen, and J. C. DeMartini. 1998. “Malignant Catarrhal Fever in Bison, Acute and Chronic Cases.” Journal of Veterinary Diagnostic Investigation 10 (3): 255–262. https://doi.org/10.1177/104063879801000305

Schultheiss, P. C., H. Van Campen, T. R. Spraker, C. Bishop, L. Wolfe, and B. Podell. 2007. “Malignant Catarrhal Fever Associated with Ovine Herpesvirus-2 in Free-Ranging Mule Deer in Colorado.” Journal of Wildlife Diseases 43 (3): 533–537. https://doi.org/10.7589/0090-3558-43.3.533

Spickler, A. R. 2019. “Malignant Catarrhal Fever.” http://www.cfsph.iastate.edu/DiseaseInfo/factsheets.php

USDA National Agricultural Statistics Service. n.d. 2022 Census of Agriculture. www.nass.usda.gov/AgCensus

Zhu, H., Q. Huang, X. Hu, W. Chu, J. Zhang, L. Jiang, X. Yu, X. Zhang, and S. Cheng. 2018. “Caprine Herpesvirus 2-Associated Malignant Catarrhal Fever of Captive Sika Deer (Cervus nippon) in an Intensive Management System.” BMC Veterinary Research 14 (1): 38. https://doi.org/10.1186/s12917-018-1365-8

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