Chagas Disease, a Triatomine Bug-Transmitted Protozoan Infection
view on EDIS
PDF 2023

Categories

How to Cite

Eutsey, Bethany R., Cameron J. Jack, Shelley A. Whitehead, and Eva A. Buckner. 2023. “Chagas Disease, a Triatomine Bug-Transmitted Protozoan Infection: ENY2104/IN1412, 7/2023”. EDIS 2023 (4). Gainesville, FL. https://doi.org/10.32473/edis-in1412-2023.

Abstract

Chagas disease is a potentially fatal, chronic disease caused by Trypanosoma cruzi, a protozoan parasite. It causes 6 to 8 million cases and 50,000 deaths each year. Humans and animals usually become infected with T. cruzi via triatomine bugs, also called kissing or conenose bugs, found only in the Americas. Disease transmitted by triatomine bugs generally occurs in rural areas of Mexico, Central America, and South America, but it is becoming more prevalent in non-endemic areas like the US as asymptomatic infected people move from rural to urban areas of Latin America and other regions.  In the US, approximately 300,000 people are currently infected with Chagas disease, 18,000 in Florida. Most if not all of them were infected elsewhere; local transmission of Chagas disease via triatomines in the US is rare. Awareness and understanding of Chagas disease are critical to detect and treat cases early. This publication is intended for anyone interested in learning more about Chagas disease.

https://doi.org/10.32473/edis-in1412-2023
view on EDIS
PDF 2023

References

Andrade, J. P. D., J. A. Marin Neto, A. A. V. D. Paola, F. Vilas-Boas, G. M. M. Oliveira, F. Bacal, E. A. Bocchi, et al. 2011. "Latin American Guidelines for the Diagnosis and Treatment of Chagas' Heart Disease: Executive Summary." Arquivos brasileiros de cardiologia 96:434–442. https://doi.org/10.1590/S0066-782X2011000600002

Añez, N., H. Carrasco, H. Parada, G. Crisante, A. Rojas, N. Gonzalez, J.L. Ramirez, et al. 1999. "Acute Chagas' Disease in Western Venezuela: A Clinical, Seroparasitologic, and Epidemiologic Study." American Journal of Tropical Medicine & Hygiene 60 (2): 215–222. https://doi.org/10.4269/ajtmh.1999.60.215

Antinori, S., L. Galimberti, R. Bianco, R. Grande, M. Galli, and M. Corbellino. 2017. "Chagas Disease in Europe: A Review for the Internist in the Globalized World." European Journal of Internal Medicine 43:6–15. https://doi.org/10.1016/j.ejim.2017.05.001

Apt, W. 2017. “Treatment of Chagas Disease.” American Trypanosomiasis Chagas Disease: One Hundred Years of Research: Second Edition. Elsevier Inc. https://doi.org/10.1016/B978-0-12-801029-7.00032-0

Aufderheide, A.C., W. Salo, M. Madden, J. Streitz, J. Buikstra, F. Guhl, B. Arriaza, et al. 2004. "A 9,000-Year Record of Chagas' Disease." Proceedings of the National Academy of Sciences 101 (7): 2034–2039. https://doi.org/10.1073/pnas.0307312101

Beatty, N. L., N. Behrens-Bradley, M. Love, F. McCants, S. Smith, J. O. Schmidt, S. A. Hamer, P. L. Dorn, N. Ahmad, and S. A. Klotz. 2019. "Rapid Detection of Human Blood in Triatomines (Kissing Bugs) Utilizing a Lateral Flow Immunochromatographic Assay—A Pilot Study." Memorias do Instituto Oswaldo Cruz 114: e190047. https://doi.org/10.1590/0074-02760190047

Beatty, N. L., and S. A. Klotz. 2018. "The Midnight Bite! A Kissing Bug Nightmare.” American Journal of Medicine 131 (2): e43–e44. https://doi.org/10.1016/j.amjmed.2017.10.013

Beatty, N. L., and S. A. Klotz. 2020. “Autochthonous Chagas Disease in the United States: How Are People Getting Infected?” The American Journal of Tropical Medicine and Hygiene 103 (3): 967–969. https://doi.org/10.4269/ajtmh.19-0733

Beatty, N.L., C.R. Bhosale, Z.S. White, C. Torhorst, K.N. Wilson, R. Dorleans, T. Stenn, et al. 2022. “Florida Kissing Bugs (Hemiptera, Reduviidae, Triatominae) Invade Homes, Feed on Diverse Hosts, and Harbor Trypanosoma cruzi.” American Society of Tropical Medicine and Hygiene 71st Annual Scientific Meeting Poster. https://doi.org/10.13140/RG.2.2.29155.63528.

Bern, C., L. A. Messenger, J. D. Whitman, and J. H. Maguire. 2020. "Chagas Disease in the United States: a Public Health Approach." Clinical Microbiology Reviews 33(1). https://doi.org/10.1128/CMR.00023-19

Bern, C., S. Kjos, M. Yabsley, and S. P. Montgomery. 2011. "Trypanosoma cruzi and Chagas Disease in the United States." Clinical Microbiology Reviews 24:655–681. https://doi.org/10.1128/CMR.00005-11

Bern, C., and S. P. Montgomery. 2009. "An Estimate of the Burden of Chagas Disease in the United States." Clinical Infectious Diseases 49:e52–4. https://doi.org/10.1086/605091

Biolo, A., A. L. Ribeiro, and N. Clausell. 2010. "Chagas cardiomyopathy-where do we stand after a hundred years?" Progress in Cardiovascular Diseases 52 (4): 300–316. https://doi.org/10.1016/j.pcad.2009.11.008

Brasil, P. E., L. De Castro, A. M. Hasslocher-Moreno, L. H. Sangenis, and J. U. Braga. 2010. "ELISA versus PCR for Diagnosis of Chronic Chagas Disease: Systematic Review and Meta-Analysis." BMC Infectious Diseases 10:337. https://doi.org/10.1186/1471-2334-10-337

Brown, W. 2015. "Kissing Bugs and Chagas Disease." Texas A&M AgriLife Extension. November 25, 2015. Accessed October 18, 2021. https://schoolipm.tamu.edu/2015/11/25/school-pest-news-volume-15-issue-11-november-2015/

Busselman, R. E., and S. A. Hamer. 2022. "Chagas Disease Ecology in the United States: Recent Advances in Understanding Trypanosoma cruzi Transmission Among Triatomines, Wildlife, and Domestic Animals and a Quantitative Synthesis of Vector-Host Interactions." Annual Review of Animal Biosciences 10:325–348. https://doi.org/10.1146/annurev-animal-013120-043949

Centers for Disease Control and Prevention (CDC). 2022a. "About Chagas Disease." April 11, 2022. Accessed September 5, 2022. https://www.cdc.gov/parasites/chagas/gen_info/detailed.html#intro

Centers for Disease Control and Prevention (CDC). 2022b. "Triatomine Bug FAQs." April 13, 2022. Accessed September 5, 2022. https://www.cdc.gov/parasites/chagas/gen_info/vectors/index.html

Centers for Disease Control and Prevention (CDC). 2021. "American Trypanosomiasis." June 16, 2021. Accessed August 22, 2022. https://www.cdc.gov/dpdx/trypanosomiasisamerican/index.html

Centers for Disease Control and Prevention (CDC). 2019a. "Bugs Commonly Confused with Triatomine Bugs." July 17, 2019. Accessed September 9, 2022. https://www.cdc.gov/parasites/chagas/gen_info/vectors/confuse.html

Centers for Disease Control and Prevention (CDC). 2019b. "Prevention and Control". March 6, 2019. Accessed August 11, 2022. https://www.cdc.gov/parasites/chagas/prevent.html.

Chao, C., J. L. Leone, and C. A. Vigliano. 2020. "Chagas Disease: Historic Perspective." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (5): 1–15. https://doi.org/10.1016/j.bbadis.2020.165689

Chatelain, E. 2017. "Chagas disease research and development: Is there light at the end of the tunnel?" Computational and Structural Biotechnology Journal 15: 98–103. https://doi.org/10.1016/j.csbj.2016.12.002

Coura, J. R. 2007. "Chagas Disease: What Is Known and What Is Needed-A Background Article." Memórias do Instituto Oswaldo Cruz 102:113–122. https://doi.org/10.1590/S0074-02762007000900018

de Oliveira, A. B. B., K. C. C. Alevi, C. H. L. Imperador, F. F. Madeira, and M. T. V. Azeredo-Oliveira. 2018. "Parasite–Vector Interaction of Chagas Disease: A Mini-Review." American Journal of Tropical Medicine and Hygiene 98 (3): 653–655. https://doi.org/10.4269/ajtmh.17-0657

Dodd, R. Y., J. A. Groves, R. L. Townsend, E. P. Notari, G. A. Foster, B. Custer, M. P. Busch, and S. L. Stramer. 2019. "Impact of One‐Time Testing for Trypanosoma cruzi Antibodies among Blood Donors in the United States." Transfusion 59:1016–1023. https://doi.org/10.1111/trf.15118

Filardi, L. S., and Z. Brener. 1987. "Susceptibility and Natural Resistance of Trypanosoma cruzi Strains to Drugs Used Clinically in Chagas Disease." Transactions of the Royal Society of Tropical Medicine and Hygiene 81 (5): 755–759. https://doi.org/10.1016/0035-9203(87)90020-4

Forsyth, C. J., J. Manne-Goehler, C. Bern, J. Whitman, N. S. Hochberg, M. Edwards, R. Marcus, et al. 2022. "Recommendations for Screening and Diagnosis of Chagas Disease in the United States." The Journal of Infectious Diseases 225 (9): 1601–1610. https://doi.org/10.1093/infdis/jiab513

Garcia-Huertas, P., and N. Cardona-Castro. 2021. "Advances in the Treatment of Chagas Disease: Promising New Drugs, Plants and Targets." Biomedicine and Pharmacotherapy 142:112020. https://doi.org/10.1016/j.biopha.2021.112020

Gunter, S. M., C. Cordray, R. Gorchakov, I. Du, B. Dittmar, E. L. Brown, K. O. Murray, and M. S. Nolan. 2018. "Identification of White-Tailed Deer (Odocoileus virginianus) as a Novel Reservoir Species for Trypanosoma cruzi in Texas, USA." Journal of Wildlife Diseases 54:814–818. https://doi.org/10.7589/2017-09-223

Gurtler, R. E., and M. V. Cardinal. 2015. "Reservoir Host Competence and the Role of Domestic and Commensal Hosts in the Transmission of Trypanosoma cruzi." Acta Tropica 151:32–50. https://doi.org/10.1016/j.actatropica.2015.05.029

Hodo, C. L., C. C. Goodwin, B. C. Mayes, J. A. Mariscal, K. A. Waldrup, and S. A. Hamer. 2016. "Trypanosome Species, Including Trypanosoma cruzi, in Sylvatic and Peridomestic Bats of Texas, USA." Acta Tropica 164:259–266. https://doi.org/10.1016/j.actatropica.2016.09.013

Irish, A., J. D. Whitman, E. H. Clark, R. Marcus, and C. Bern. 2022. "Updated Estimates and Mapping for Prevalence of Chagas Disease among Adults, United States." Emerging Infectious Diseases 28 (7): 1313–1320. https://doi.org/10.3201/eid2807.212221

Klotz, S. A., J. O. Schmidt, P. L. Dorn, C. Ivanyi, K. R. Sullivan, and L. Stevens. 2014. "Free-Roaming Kissing Bugs, Vectors of Chagas Disease, Feed Often on Humans in the Southwest." The American Journal of Medicine 127:421–426. https://doi.org/10.1016/j.amjmed.2013.12.017

Levesque, B. 2021. "UF Health Scientists Study Prevalence of a Kissing Bug Disease among Latin Americans in Florida." University of Florida Health. February 8, 2021. Accessed August 12, 2022. https://ufhealth.org/news/2021/uf-health-scientists-study-prevalence-kissing-bug-disease-among-latin-americans-florida

Lidani, K. C. F., F. A. Andrade, L. Bavia, F. S. Damasceno, M. H. Beltrame, I. J. Messias-Reason, and T. L. Sandri. 2019. "Chagas Disease: From Discovery to a Worldwide Health Problem." Frontiers in Public Health 7:166. https://doi.org/10.3389/fpubh.2019.00166

Lima-Costa, M. F., D. L. Matos, and A. L. Ribeiro. 2010. "Chagas Disease Predicts 10-Year Stroke Mortality in Community-Dwelling Elderly: The Bambuí Cohort Study of Aging." Stroke 41:2477–2482. https://doi.org/10.1161/STROKEAHA.110.588061

Liu, Q., and X. N. Zhou. 2015. "Preventing the Transmission of American Trypanosomiasis and Its Spread into Non-Endemic Countries." Infectious Diseases of Poverty 4 (60): 1–11. https://doi.org/10.1186/s40249-015-0092-7

Lopez-Velez, R., F. F. Norman, and C. Bern. 2019. "American Trypanosomiasis (Chagas Disease)." In Hunter's Tropical Medicine and Emerging Infectious Disease, edited by E. T. Ryan, D. R. Hill, T. Solomon, T. P. Endy, and N. Aronson. 10th ed Elsevier; London, United Kingdom: pp. 762–765. https://doi.org/10.1016/B978-0-323-55512-8.00103-4

Luquetti, A. O., and G. A. Schmunis. 2017. “Diagnosis of Trypanosoma cruzi Infection.” p. 687-730. In American Trypanosomiasis Chagas Disease, edited by J. Telleira and M. Tibayrenc. Elsevier, Amsterdam, Netherlands. https://doi.org/10.1016/B978-0-12-801029-7.00030-7

Lynn, M. K., B. H. Bossak, P. A. Sandifer, A. Watson, and M. S. Nolan. 2020. “Contemporary Autochthonous Human Chagas Disease in the USA.” Acta Tropica 205:105361. https://doi.org/10.1016/j.actatropica.2020.105361

Montgomery, S. P., M. E. Parise, E. M. Dotson, and S. R. Bialek. 2016. "What do we know about chagas disease in the United States?" American Journal of Tropical Medicine and Hygiene 95:1225–1227. https://doi.org/10.4269/ajtmh.16-0213

Morillo, C. A., J. A. Marin-Neto, A. Avezum, S. Sosa-Estani, A. Rassi Jr., F. Rosas, E. Villena, R. Quiroz, R. Bonilla, C. Britto, and F. Guhl. 2015. "Randomized Trial of Benznidazole for Chronic Chagas' Cardiomyopathy." New England Journal of Medicine 373:1295–306. https://doi.org/10.1056/NEJMoa1507574

Ortiz-Medina, A., and S. Pons. 1974. "Manifestaciones cutáneas de la enfermedad de Chagas. Cuarta parte: Histopatología." Medicina Cutánea Ibero-Latino-Americana 2:391–397.

Patel, S., and A. Sethi. 2009. "Imported Tropical Diseases." Dermatological Therapy 22:538–549. https://doi.org/10.1111/j.1529-8019.2009.01275.x

Prata, A. 2001. "Clinical and Epidemiological Aspects of Chagas Disease." The Lancet Infectious Diseases 1:92–100. https://doi.org/10.1016/S1473-3099(01)00065-2

Ramsey, J. M., and C. J. Schofield. 2003. "Control of Chagas Disease Vectors." Salud Publica de Mexico 45 (2): 123–128. https://doi.org/10.1590/S0036-36342003000200010

Rassi Jr., A., A. Rassi, and J. A. Marin-Neto. 2010. "Chagas Disease." The Lancet 375 (9723): 1388–1402. https://doi.org/10.1016/S0140-6736(10)60061-X

Steverding, D. 2014. "The History of Chagas Disease." Parasites & Vectors 7 (317): 1–8. https://doi.org/10.1186/1756-3305-7-317

Webber, B. J., M. T. Pawlak, S. Valtier, C. C. Daniels, C. C. Tully, E. J. Wozniak, W. D. Roachell, F. X. Sanchez, A. A. Blasi, and T. L. Cropper. 2017. "Prevalence and Seroprevalence of Trypanosoma cruzi Infection in a Military Population in Texas." American Journal Tropical Medicine and Hygiene 97:1477–1481. https://doi.org/10.4269/ajtmh.17-0109

Wisely, S., and N. Beatty. 2021. "Chagas Disease—A Health Risk for Rural People in the Southeastern U.S." October 1, 2021. Panhandle Ag e-News UF/IFAS Extension. Accessed September 3, 2022. https://nwdistrict.ifas.ufl.edu/phag/2021/10/01/chagas-disease-a-health-risk-for-rural-people-in-the-southeastern-u-s/

World Health Organization (WHO) Expert Committee on the Control of Chagas Disease (‎2000: Brasilia, Brazil)‎ & World Health Organization. 2002‎. Control of Chagas Disease: Second Report of the WHO Expert Committee. https://apps.who.int/iris/handle/10665/42443

World Health Organization (WHO). 2022. "Chagas Disease (Also Known as American Trypanosomiasis)." April 13, 2022. Accessed December 8, 2022. https://www.who.int/news-room/fact-sheets/detail/chagas-disease-(american-trypanosomiasis).

World Health Organization (WHO). 2015. "Chagas Disease in Latin America: An Epidemiological Update Based on 2010 Estimates." Weekly Epidemiological Records 90:33–44. https://apps.who.int/iris/bitstream/handle/10665/242316/WER9006_33-44.PDF?sequence=1&isAllowed=y.

Zeledon, R., C. B. Beard, J. C. Pinto Dias, D. A. Leiby, P. L. Dorn, and J. R. Coura. 2012. "Triatomine Bug Vectors." In An Appraisal of the Status of Chagas Disease in the United States. Elsevier; Waltham, MA, USA: pp. 5–C1. https://doi.org/10.1016/B978-0-12-397268-2.00002-X

Copyright (c) 2023 UF/IFAS