Contaminants in the Urban Environment: Pharmaceuticals and Personal Care Products (PPCPs)—Part 2
Common pharmaceutical and personal care products (PPCPs) in households
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Contaminants in the Urban Environment series


How to Cite

Yang, Yun-Ya, and Gurpal S. Toor. 2015. “Contaminants in the Urban Environment: Pharmaceuticals and Personal Care Products (PPCPs)—Part 2: Sl420/SS633, 3/2015”. EDIS 2015 (3). Gainesville, FL:9.


Pharmaceuticals and personal care products contain a variety of chemical substances that enter household wastewater from bath and shower, sinks, and washers and ultimately find their way into the environment. Continuous discharge of wastewater contributes to the accumulation of these substances in the environment — where they can be harmful to organisms. This publication is part of a series titled Contaminants in the Urban Environment. This series is intended to give state and local government officials, soil scientists, consulting engineers, extension agents, and citizens (1) a basic understanding of the occurrence, toxic effects, and source of various contaminants in the environment and (2) guidance on ways to protect human and environmental health. This 9-page fact sheet discusses the sources and impacts of PPCPs and offers common-sense ways we can protect our environment from PPCPs. Written by Yun-Ya Yang and Gurpal S. Toor, and published by the UF Department of Soil and Water Science, March 2015.

SL420/SS633: Contaminants in the Urban Environment: Pharmaceuticals and Personal Care Products (PPCPs)—Part 2 (
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Barnes, K. K., D. W. Kolpin, E. T. Furlong, S. D. Zaugg, M. T. Meyer, and L. B. Barber. 2008. "A National Reconnaissance of Pharmaceuticals and Other Organic Wastewater Contaminants in the United States - I) Groundwater." Science of the Total Environment 402: 192-200.

Benotti, M. J., R. A. Trenholm, B. J. Vanderford, J. C. Holady, B. D. Stanford, and S. A. Snyder. 2009. "Pharmaceuticals and Endocrine Disrupting Compounds in US Drinking Water." Environmental Science and Technology 43: 597-603.

Bound, J. P., and N. Voulvoulis. 2005. "Household Disposal of Pharmaceuticals as a Pathway for Aquatic Contamination in the United Kingdom." Environmental Health Perspectives 113: 1705-1711.

Boxall, A. B. A. 2004. "The Environmental Side Effects of Medication." EMBO Rep 5: 1110-1116.

Center for Disease Control and Prevention. 2013. "Frequently Asked Questions about Antibiotic Resistance and Food Safety." Accessed February 10, 2014.

Dussault, È. B., V. K., Balakrishnan, E. Sverko, K. R. Solomon, and P. K. Sibley. 2008. "Toxicity of Human Pharmaceuticals and Personal Care Products to Benthic Invertebrates." Environmental Toxicology and Chemistry 27: 425-432.

Ellis, J. B. 2006. "Pharmaceutical and personal care products (PPCPs) in urban receiving waters." Environmental Pollution 144: 184-189.

Focazio, M. J., D. W. Kolpin, K. K. Barnes, E. T. Furlong, M. T. Meyer, S. D. Zaugg, L. B. Barber, and M. E. Thurman. 2008. "A National Reconnaissance for Pharmaceuticals and Other Organic Wastewater Contaminants in the United States - II) Untreated Drinking Water Sources." Science of the Total Environment 402: 201-216.

Fram, M. S., and K. Belitz. 2011. "Occurrence and Concentrations of Pharmaceutical Compounds in Groundwater Used for Public Drinking-Water Supply in California." Science of the Total Environment 409: 3409-3417.

Heuer, H., and K. Smalla. 2007. "Manure and Sulfadiazine Synergistically Increased Bacterial Antibiotic Resistance in Soil Over at Least Two Months." Environmental Microbiology 9: 657-666.

Holling, C. S., J. L. Bailey, B. V. Heuvel, and C. A. Kinney. 2012. "Uptake of Human Pharmaceuticals and Personal Care Products by Cabbage (Brassica campestris) from Fortified and Biosolids-Amended Soils." Journal of Environmental Monitoring 14: 3029-3036.

Hollis, A., and Z. Ahmed. 2013. "Preserving antibiotics, rationally." New England Journal of Medicine 369: 2474-2476.

Ibotson, Anna. 2009. "Market Research: Consumer Products Show Promise for Specialty Chemicals." Accessed December 17, 2013.

Ishibashi, H., N. Matsumura, M. Hirano, M. Matsuoka, H. Shiratsuchi, Y. Ishibashi, Y. Takao, and K. Arizono. 2004. "Effects of Triclosan on the Early Life Stages and Reproduction of Medaka Oryzias latipes and Induction of Hepatic Vitellogenin." Aquatic Toxicology 67: 167-179.

Jobling, S., D. Casey, T. Rodgers-Gray, J. Oehlmann, U. Schulte-Oehlmann, S. Pawlowski, T. Baunbeck, A. P. Turner, and C. R. Tyler. 2003. "Comparative Responses of Molluscs and Fish to Environmental Estrogens and an Estrogenic Effluent." Aquatic Toxicology 65: 205-220.

Kim, S. C., J. G. Davis, C. C. Truman, J. C. Ascough, and K. Carlson. 2010. "Simulated Rainfall Study for Transport of Veterinary Antibiotics-Mass Balance Analysis." Journal of Hazardous Materials 175: 836-843.

Kinney, C. A., E. T. Furlong, S. L. Werner, and J. D. Cahill. 2006. "Presence and Distribution of Wastewater-Derived Pharmaceuticals in Soil Irrigated with Reclaimed Water." Environmental Toxicology and Chemistry 25: 317-326.

Kolpin, D. W., E. T. Furlong, M. T. Meyer, E. M. Thurman, S. D. Zaugg, L. B. Barber, and H. T. Buxton. 2002. "Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999-2000: A National Reconnaissance." Environmental Science and Technology 36: 1202-1211.

Lapworth, D. J., N. Baran, M. E. Stuart, and R. S. Ward. 2012. "Emerging Organic Contaminants in Groundwater: A Review of Sources, Fate and Occurrence." Environmental Pollution 163: 287-303.

Lienert, J., K. Güdel, B. I. Escher. 2007. "Screening Method for Ecotoxicological Hazard Assessment of 42 Pharmaceuticals Considering Human Metabolism and Excretory Routes." Environmental Science and Technology 41: 4471-4478.

Ma, T., X. Wan, Q. Huang, Z. Wang, and J. Liu. 2005. "Biomarker Responses and Reproductive Toxicity of the Effluent from a Chinese Large Sewage Treatment Plant in Japanese medaka (Oryzias latipes)." Chemosphere 59: 281-288.

Miller, K. J., and J. Meek. 2006. "Helena Valley Ground Water: Pharmaceuticals, Personal Care Products, Endocrine Disruptors (PPCPs) and Microbial Indicators of Fecal Contamination." Montana Bureau of Mines and Geology, Open File Report 532.

National Center for Health Statistics. 2013. "Health, United States, 2012: With Special Feature on Emergency Care." Hyattsville, MD.

Oosterhuis, M., F. Sacher, and T. L. ter Laak. 2013. "Prediction of Concentration Levels of Metformin and Other High Consumption Pharmaceuticals in Wastewater and Regional Surface Water Based on Sales Data." Science of the Total Environment 442: 380-388.

Peak, N., C. W. Knapp, R. K. Yang, M. M. Hanfelt, M. S. Smith, D. S. Aga, and D. W. Graham. 2007. "Abundance of Six Tetracycline Resistance Genes in Wastewater Lagoons at Cattle Feedlots with Different Antibiotic use Strategies." Environmental Microbiology 9: 143-151.

Pinheiro, A., R. M. Rosa Albano, T. C. Alves, V. Kaufmann, and M. R. da Silva. 2013. "Veterinary Antibiotics and Hormones in Water from Application of Pig Slurry to Soil." Agricultural Water Management 129: 1-8.

Richmond, E. K., M. R. Grace, J. J. Kelly, A. J. Reisinger, E. J. Rosi, and D. M. Walters. 2017. "Pharmaceuticals and personal care products (PPCPs) are ecological disrupting compounds (EcoDC)." Elementa: Science of the Anthropocene 5: 66.

Rosi, E. J., H. A. Bechtold, D. Snow, M. Rojas, A. J. Reisinger, and J. J. Kelly. 2018. "Urban stream microbial communities show resistance to pharmaceutical exposure." Ecosphere 9: e02041.

Sabourin, L., P. Duenk, S. Bonte-Gelok, M. Payne, D. R. Lapen, and E. Topp. 2012. "Uptake of Pharmaceuticals, Hormones and Parabens into Vegetables Grown in Soil Fertilized with Municipal Biosolids." Science of the Total Environment 431: 233-236.

Stackelberg, P. E., E. T. Furlong, M. T. Meyer, S. D. Zaugg, A. K. Henderson, and D. B. Reissman. 2004. "Persistence of Pharmaceutical Compounds and Other Organic Wastewater Contaminants in A Conventional Drinking-Water Treatment Plant." Science of the Total Environment 329: 99-113.

Tamura, I., K. Kagota, Y. Yasuda, S. Yoneda, J. Morita, N. Nakada, Y. Kameda, K. Kimura, N. Tatarazako, and H. Yamamoto. 2013. "Ecotoxicity and Screening Level Ecotoxicological Risk Assessment of Five Antimicrobial Agents: Triclosan, Triclocarban, Resorcinol, Phenoxyethanol and p-thymol." Journal of Applied Toxicology 33: 1222-1229.

Ternes, T. A., M. Meisenheimer, D. McDowell, F. Sacher, H. Brauch Jr., B. Haist-Gulde, G. Preuss, U. Wilme, and N. Zulei-Seibert. 2002. "Removal of Pharmaceuticals during Drinking Water Treatment." Environmental Science and Technology 36: 3855-3863.

Toor, G. S., M. Lusk, and T. Obreza. 2011. Onsite Sewage Treatment and Disposal Systems: Trace Organic Chemicals. Gainesville: University of Florida Institute of Food and Agricultural Sciences.

United States Environmental Protection Agency (US EPA). 2009. How to Dispose of Medicines Properly.

United States Food and Drug Administration. 2013. "How to Dispose of Unused Medicines." Accessed February 10, 2014.

United States Pharmaceutical Statistics. 2013. "US Pharmaceuticals Sales-2012." Accessed December 2, 2013.

Vajda, A. M., L. B. Barber, J. L. Gray, E. M. Lopez, J. D. Woodling, and D. O. Norris. 2008. "Reproductive Disruption in Fish Downstream from an Estrogenic Wastewater Effluent." Environmental Science and Technology 42: 3407-3414.

Whitacre, D. M. 2011. "Reviews of Environmental Contamination and Toxicology." Springer 202: 79-84.

Xu, H., J. Yang, Y. Wang, Q. Jiang, H. Chen, and H. Song. 2008. "Exposure to 17α-ethynylestradiol Impairs Reproductive Functions of Both Male and Female zebrafish (Danio rerio)." Aquatic Toxicology 88: 1-8.

Zha, J., Z. Wang, N. Wang, and C. Ingersoll. 2007. "Histological Alternation and Vitellogenin Induction in Adult Rare Minnow (Gobiocypris rarus) after Exposure to Ethynylestradiol and Nonylphenol." Chemosphere 66: 488-495.

Zhang, Y., and S.-U. Geißen. 2010. "Prediction of Carbamazepine in Sewage Treatment Plant Effluents and Its Implications for Control Strategies of Pharmaceutical Aquatic Contamination." Chemosphere 80: 1345-1352.

Zhang, Y., S.-U. Geißen, and C. Gal. 2008. "Carbamazepine and Diclofenac: Removal in Wastewater Treatment Plants and Occurrence in Water Bodies." Chemosphere 73: 1151-1161.