A Case Study of Representing Signal Transduction in Liver Cells as A Feedback Control Problem

Autores

  • Abhay Singh Texas A&M University
  • Arul Jayaraman Texas A&M University
  • Juergen Hahn Texas A&M University

Resumo

Cell signaling pathways often contain feedback loops where proteins are produced that regulate signaling. While feedback regulatory mechanisms are commonly found in signaling pathways, there is no example available in the literature that is simple enough to be presented in an undergraduate control class. This paper presents a simulation study of cell signaling in liver cells where it is shown that the cellular regulatory response can be represented by linear transfer functions for certain levels of stimulation.

Biografia do Autor

Abhay Singh, Texas A&M University

Abhay Singh is a Ph.D. student at Texas A&M University, College Station. He received his B.E. in chemical engineering from Panjab University, Chandigarh, India in 1998. Afterward, he joined Indian Petrochemicals Corporation Ltd. (IPCL) as a production engineer (Chemical) for four years. His research interests include sensor location, soft sensor design, and systems biology. He is a recipient of the CPC 7 Outstanding Contributed Paper Award.

Arul Jayaraman, Texas A&M University

Arul Jayaraman received his B.E. (Hons) in chemical engineering and M.S. (Hons) in physics from BITS Pilani, India, in 1992, his M.S. from Tufts University in 1994, and his Ph.D. from the UniversityofCalifomia, Irvine, in 1998, both in chemical engineering. He joined Harvard Medical School as instructor in bioengineering in 2000. He joined Texas A&M University, College Station, as an assistant professor in 2004. His research interests include systems biology, molecular bioengineering, and cell-cell communication.

Juergen Hahn, Texas A&M University

Juergen Hahn received his degree in engineering from RWTH Aachen, Germany, in 1997, and his M.S. and Ph.D. degrees in chemical engineering from the University of Texas, Austin, in 1998 and 2002, respectively. He joined Texas A&M University, College Station, as an assistant professor in 2003. His research interests include process modeling and analysis, systems biology, and nonlinear model reduction. He has published more than 30 articles and book chapters.

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Publicado

2007-07-01

Edição

v. 41 n. 3 (2007): Summer 2007

Seção

Manuscripts