Two-Compartment Pharmacokinetic Models for Chemical Engineers


  • Kumud Kanneganti New Jersey Institute of Technology
  • Laurent Simon New Jersey Institute of Technology


The transport of potassium permanganate between two continuous-stirred vessels was investigated to help chemical and biomedical engineering students understand two-compartment pharmacokinetic models. Concepts of modeling, mass balance, parameter estimation and Laplace transform were applied to the two-unit process. A good agreement was achieved between experimental and predicted data. The setup was used by a group of students who studied the effects of dose size on the concentrations of potassium permanganate in the two vessels.

Author Biographies

Kumud Kanneganti, New Jersey Institute of Technology

Kumud Kanneganti is pursuing a Master’s degree in the Otto H. York Department of Chemical, Biological, and Pharmaceutical Engineering. He received a B. Tech. degree in chemical engineering from Nirma University of Science and Technology (NU), India. His research focus is in the design of drug delivery strategies using well-stirred vessel experiments.

Laurent Simon, New Jersey Institute of Technology

Laurent Simon is an associate professor of chemical engineering and the associate director of the Pharmaceutical Engineering Program at the New Jersey Institute of Technology. He received his Ph.D. in chemical engineering from Colorado State University in 2001. His research and teaching interests involve modeling, analysis, and control of drug-delivery systems. He is the author of Laboratory Online, available at <>, a series of educational and interactive modules to enhance engineering knowledge in drug-delivery technologies and underlying engineering principles.