Recent expeditions to the Cordillera del Condor in southeastern Ecuador have uncovered three new species of Orchidaceae, subtribe Pleurothallidinae. Brachionidium condorense L.J. Jost, B. deflexum L.J. Jost, and Lepanthes neillii L.J. Jost are described. The overall species composition of the primarily epiphytic genus Lepanthes in the Cordillera del Condor is similar to that of other front-line foothill ranges in the eastern Andes of Ecuador. The species composition of primarily terrestrial Brachionidium, on the other hand, appears to be unusual and distinctive.