Two field trials, one each in 2000 and 2001, were conducted to determine the effects of using combinations of Mi-gene resistant tomatoes and methyl bromide chemical alternatives on root galling and yield of a succeeding cantaloupe crop. The sites were on loamy sand soils in northern Florida U.S.A infested with Meloidogyne javanica. Chemical treatments served as main plots, each replicated six times, and Mi-gene resistant and susceptible tomato cultivars served as subplots. Soil fumigants applied in the tests were 1,3-D, 1,3-D + 17% chloropicrin, 1,3-D + 35% chloropicrin, and a standard methyl bromide + 33% chloropicrin treatment. The tomato and the succeeding cantaloupe crops were grown on polyethylene mulch and irrigated through drip tubing. In both the 2000 and 2001 tests, chemical treatments and use of Mi-gene resistant tomato cultivars reduced root galling on the tomato crop. Root galling on the subsequent cantaloupe crops were not affected by chemical treatment of the previous tomato crop, but cantaloupe yield was increased. Root galling on cantaloupe grown after resistant tomato cultivars was significantly reduced, and use of first crop Mi-resistant tomato increased cantaloupe yield and fruit number. Reduced root galling and increased yield of cantaloupe was generally found when using chemical soil treatment and Mi-gene resistance in a first tomato crop.