New genera and species of putatively mimetic Cleridae (Coleoptera: Cleroidea) are described from Mexico and Central America: Namba testacea, new genus and species from Nuevo León, Mexico; Aulicoides leavengoodi, new genus and species from Jalisco, Mexico; and Quadrophenia, new genus, which includes Q. townshendi, new species, from Mexico, Nicaragua, Costa Rica and Panama, Q. mooni, new species, from Costa Rica, Q. entwistlei, new species, from Guatemala and Honduras, Q. daltreyi, new species, from Costa Rica, and Q. sumideronew species, from Chiapas, Mexico. A key to the species of Quadrophenia is provided. All of the newly described species are hypothesized to be Batesian mimics of aposematically colored coleopteran models, some of which are known to be chemically protected.