Bovine placental-derived bio-ink reprograms tissue microenvironment for enhanced regeneration and senescence reversal

Authors

DOI:

https://doi.org/10.32473/ufjur.28.141722

Keywords:

Bioink, Biomaterials, Regenerative, Anti-senescence, Extracellular vesicle

Abstract

Chronic wound care seeks natural biomimetic materials to improve the regeneration of functional tissues while reversing the damage-induced state that impairs healing. This study proposes a bovine placental-derived natural bio-ink for 3D printing, composed of droplets encapsulating placental collagen type I (COL 1) and amniotic fluid-derived extracellular vesicles (AF-EVs). It hypothesizes that COL 1 from bovine placenta can better replicate human tissue environments, leveraging placenta’s rich regenerative and biochemical properties. Amniotic fluid is a rich source of EVs, which have demonstrated anti-inflammatory, angiogenic, regenerative and anti-senescent properties. A bioink combining these components provides both structural support and the potential to reprogram the wound microenvironment of chronic wounds.

Here, it is shown that bovine placental collagen exhibits high purity and enhanced biocompatibility compared to commercial collagen, while AF-EVs improve wound closure and reduce markers of cellular senescence.

Together, these findings support the use of a placental-derived bioink for promoting regeneration and restoring function in chronic wounds.

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Published

2026-09-21

Issue

Vol. 28 (2026): UF Journal of Undergraduate Research

Section

STEM & Medicine

License

Copyright (c) 2026 Fabiana Mastantuono, Samantha Ali, Pei Zhuang, Giovanna Scatolin, Zongliang (Carl) Jiang, Mei He

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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